帕金森病与痴呆

Parkinson's disease and dementia

为探讨帕金森病痴呆的发生率和痴呆的类型，对３０例患者和２６例正常人进行神经心理测验。结果表明：ＨＲＢ（Ａ）－ＲＣ测验脑损伤指数（ＤＱ）为６３．６４％脑损害。ＷＡＩＳ－ＲＣ及ＷＭＳ测验智力商数（ＩＱ）、记忆商数（ＭＱ）分别为２０％和６０％轻至极重度损害。６例（２０％）符合痴呆诊断，其中皮质下痴呆４例，混合性痴呆２例。讨论了病程与痴呆的关系；指出应早期发现智能障碍，早期治疗，以利于预防或延缓痴呆的发生。

Neuropsychological tests were carried out in 30 patients with Parkinson's disease and 26 healthy controls. The results showed that the average scores of HRB(A)-RC test were above the limited scores, 45.45%～86.36% cases being over the limited scores (P<0.01), except speechsound perception test. Damage degrees (DQ) from the least to the most serious were 63.64%. WAIS-RC test and WMS test showed that the average scores of IQ and MQ in patients were lower than those in the normal. The difference of IQ, MQ scores between patients and controls was very significant (P<0.01). The damaged cases of IQ, MQ from the least to the most serious were 20% and 60%, respectively. This indicated that the patients with Parkinson's disease were obviously damaged in intellegence and memory. In this article, there were 6 cases (20%) fitted the diagnostic standard of dementia, among them, 4 were subcortical dementia and 2 cases were complex dementia. We found that the differences between the course and IQ, MQ were very significant (P<0.05), but not between the course and DQ. It is implied that in the very early stage, the patients could appear abnormal in neuropsychology, and the intellegence and memory may be damaged more seriously in longer course. The result suggests that the early diagnosis and prompt intervention is important to prevent the occurrence and advance of dementia.