HPV感染与年轻宫颈癌的关系

Relationship Between Human Papillomavirus Infection and Cervical Cancer in Young Women

目的探讨人乳头瘤病毒(HPV)感染与年轻妇女宫颈癌的关系。方法分析常德市2004年1月-2008年10月72例(年龄小于35岁)宫颈癌患者的发病年龄,并对其肿瘤组织或分泌物进行HPV检测。结果年轻宫颈癌例数与同期宫颈癌总数之比逐年上升,差异有统计学意义(P<0.05);年轻宫颈癌中宫颈腺癌等非鳞癌总的构成比明显高于同期大于35岁宫颈癌患者中非鳞癌所占比例,两者差异有统计学意义(P<0.05)。结论年轻妇女宫颈癌的发病率呈上升趋势,与HPV感染有相关性。故应加强对HPV感染高危人群的监测、随访,做好宫颈癌的早期诊断和治疗。

Objective To explore the relationship between human papillomavirus （HPV） infection and the incidence of cervical cancer in young women. Methods The age distribution of 72 patients with cervical cancer aged below 35 years selected from Changde several hospitals from January, 2004 to October, 2008 was analyzed. The cancer tissues and cervical secretion of the patients were detected for HPV. Results The ratio between the number of cervical cancer cases in young patients and the total number of cervical cancer cases during the same period was increased year by year, and the difference was statistically significant （P〈 0.05）. The proportion of adenocarcinoma in young patients with cervical carcinoma was significantly higher than the proportion of cervical squamous cell carcinoma in cervical carcinoma patients aged over 35 years, and the difference was statistically significant （P〈 0.05）, Conclusions The incidence of cervical cancer in young women is gradually increasing, and the increase is correlated with HPV infection. We must strengthen the monitoring program and the following-up of HPV infection in high- risk population, and do well in the early diagnosis and treatment of cervical cancer.