2型糖尿病肾病患者血清同型半胱氨酸的检测及其临床意义

Determination of Serum Homocysteine in Type 2 Diabetes Nephropathy and Its Clinical Significance

目的探讨同型半胱氨酸(HCY)与2型糖尿病(T2DM)肾病患者的关系及其临床意义。方法将118例2型糖尿病患者分为三组:无肾病组、早期肾病组和临床蛋白尿组,分别检测其血清总同型半胱氨酸水平,并与对照组比较。结果与对照组比较,T2DM患者血清tHCY水平显著升高(P<0.01)。早期肾病组、临床蛋白尿组HCY与无肾病组比较差异有统计学意义(P<0.01);临床蛋白尿组与早期肾病组比较差异有统计学意义(P<0.01),并随着蛋白尿的增多而血清HCY也相应增加。结论高HCY血症可能是糖尿病肾病的一个独立的危险因素,检测糖尿病患者血清HCY水平有助于监测、判断T2DM的发生发展。

Objective To explore the relationship between homocysteine （HCY） and type 2 diabetes nephropathy and evaluate its clinical significance. Methods Totally 118 type 2 diabetic patients were classified into normal proteinuria group （n= 37）, incipient diabetic nephropathy group （n= 44）, and uremia group （n = 37）. The serum homocysteine levels of 118 patients and 55 healthy controls were detected and compared. Results Mean serum homocysteine levels of three experiment groups were significantly higher than that of control group（P〈 0.01）. There were statistically significant differences in serum homocysteine level between normal proteinuria group and incipient diabetic nephropathy group or uremia group（P〈 0.01）, as well as between incipient diabetie nephropathy group and uremia group（P〈 0.01）. With serum HCY level increased, nephropathy in type 2 diabetic patient would be severe. Conclusions Hyperhomocysteinemia may be an independent risk factor for diabetic nephropathy. The determination of the serum HCY level could be beneficial to clinical evaluation of the occurrence and development of T2DM.