摘要
羧基末端结合有糖基化磷脂酰肌醇(GPI)结构的膜蛋白,称为GPI锚定蛋白(glycosylphosphatidy-linositol-anchored protein);它们功能广泛,涉及细胞识别、生长、分化和程序性死亡等重要生命过程,与许多疾病有着一定的联系。人体内水解GPI锚定蛋白中的肌醇磷酸酯键的只有糖基化磷脂酰肌醇特异性磷脂酶D(glycosylphosphatidy-linositol spe-cific phospholipaseD GPI-PLD)。本文概述了近年来有关GPI锚定蛋白的研究状况,包括它的结构、组成、功能和水解酶GPI-PLD,GPI锚定蛋白与白血病的发生、发展及治疗等的相关性研究。
Glycosylphosphatidy- linositol - anchored protein is a kind of plasmid membrance protein which integrates glycosyl- phosphatidylinositol （GPI） structure by carboxyl terminal. They take part in some important activities, such as cell recognition, cell producing, cell differentiation, programmed cell death and so on. They have connection with many diseases. Glycosyl- phosphatidylinositol - specific phospholipase D （GPI - PLD） has been confirmed to be the only enzyme which can specifically hydrolyze GPI and release GPI - anchored proteins. It has been confirmed there is the only gene of GPI - PLD. The article summarizes the research of glycosyl- phosphatidylinositol anchored protein and its relativity with the occurrence, development, and treatment of leukemia.
出处
《实用预防医学》
CAS
2009年第4期1325-1328,共4页
Practical Preventive Medicine
关键词
GPI锚定蛋白
自血病
GPI—PLD
Glycosylphosphatidy- linositol - anchored protein
Leukemia
GPI - PLD
