槲寄生中的化学成分及其抗肿瘤活性(Ⅰ)(英文)

Chemical Constituents from Viscum coloratum(Kom.) Nakai and Their Antitumor Activities(Ⅰ)

从槲寄生75%乙醇提取物中分离得到4个化合物,应用波谱学方法鉴定它们的结构为尼克酰胺(1),乙酰胺(2),齐墩果酸(3),β-香树脂醇乙酸酯(4)。其中,化合物1和2为首次从槲寄生属植物中分离得到。采用MTT法对化合物1～4进行体外抗肿瘤活性研究,结果显示化合物1、2和4对HO-8910人卵巢浆液性腺癌、SMMC7721人肝癌、T24人膀胱癌、HepG2人肝癌和SHG人神经胶质瘤细胞系没有细胞毒活性,化合物3则对这五种肿瘤细胞系有显著的抑制作用。

Four chemical constituents were isolated from the 75 % ethanol extract of Viscum coloratum （ Kom. ） Nakai and their structures were identified as nicotinamide （ 1 ）, acetamide （2）, oleanolic acid （3） ,β-amyrin acetate （4） by spectral methods. The antitumor activities of compounds 1-4 were studied by MTT method in vitro. Compounds 1,2 and 4 showed no cytotoxic activities against HO-8910 human ovary serous adenocarcinoma, SMMC7721 human hepatoma; T24 human bladder cancer; HepG2 human hepatoma and SHG human glioma cell lines, and compound 3 showed significant inhibitory activities against those five human tumor cell lines.