含NSG残基取代的RGD相关肽的固相合成

Solid-Phase synthesis of RGD related peptides containing imino-diacetic acid

目的:应用固相肽合成方法制备RGD肽类似物。方法:用NSG残基Ida代替Asp,用酰甲胺或酰乙胺代替C末端的羧基,生成N取代类肽型的产物。结果:五个RGD肽类似物结构经LC-MS分析证明,总收率均在85%以上。结论:通过本合成工作,为建立经济、可行的类肽合成提供了一种途径。

Objective： To synthesize five RGD related peptoides on solid support. Methods- Asp and C - terminal carboxyl group were replaced by Ida （imino -diacetic acid） residue and N -methyl（ or ethyl） amide moiety respectively to produce five peptoides with several substituents on nitrogen. Results： All N - substituted peptoides were synthisized with total yields over 85%, and analyzed by LC - MS. Conclusion： It would be meaningful that an economical method for the synthesis of peptoids is possible.