摘要
目的 观察异烟肼对氯丙嗪血浓度及疗效的影响。方法 对25例单用氯丙嗪的精神分裂症合并肺结核住院患者,以异烟肼与安慰剂进行双盲对照比较。结果 服药前、服药后2天及4周末异烟肼组氯丙嗪血浓度、BPRS分值与对照组比较均无明显差异。结论 常用量异烟肼对氯丙嗪血浓度无明显影响,亦未使精神症状加重,完全适用于伴肺结核的精神病人抗痨之用。
To observe the influence of isoniazid to the blood concentration of chlorpromazine and its efficacy. Methods: 25 schizophrenic inpatients isoniazid and placebo respectively, who are complicated by pulmonary tuberculosis were treated only with chlorpromazine donble-blindly with isoniazid and placebo(14 isoniazid and 11 placebo). Results: The concentration of chlorpromazine has no significant differences between the group taking isoniazid and that of the control before, and 2 days, 4 weeks after medication, while there are no significant differences on the scores of BPRS. Conclusion: The common dose of isoniazid has no obvious influence to the concentration of chlorpromazine and the psychiatric symptoms, so it seems that isoniazid can be adapted in antituberculotic treatment of psychotic patients complicated with pulmonary tuberculosis.
出处
《上海精神医学》
1998年第2期87-88,共2页
Shanghai Archives of Psychiatry
