坏疽性脓皮病11例临床分析报告

Analysis of 11 cases of pyoderma gangrenosum

报告１１例坏疽性脓皮病，均有不同程度皮肤损害，伴发热等全身症状和其它脏器累及，其中以肺部累及较为突出。对本病的治疗应在了解全身病情的基础上以全身使用皮质类固醇激素为主，控制剂量相当于强的松０．５～１ｍｇ／（ｋｇ．ｄ），必要时辅助应用免疫抑制剂，及时处理并发症。全身用抗生素只有辅助作用，局部治疗有利于控制感染和促进皮损愈合。

Eleven cases of pyoderma gangrenosum(PG) are reported. As a necrotizing and ulcerative cutaneous disease, pyoderma gangrenosum is commonly associated with systemic illnesses, such as fever and visceral involvement. In this group, pulmonary involvements were found in 4 cases including 1 case with bronchomucous ulceration. The management for PG involves a general supportive approach to the patient with investigations to establish the diagnosis and exclude similar diseases. Besides appropriate treatment of the possible systemic diseases including antibiotic treatment to secondary infection, systemic application of prednisone at 0.5 to 1.0mg/kg daily were proven to be efficient for controlling PG except few cases may need additional application of immunosuppressive agents. Topical therapies were used towards prevention of secondary infection to improve the sure of skin lesions.