无创通气对慢性呼吸衰竭患者血栓前状态的影响

Study of non-invasive ventilation on the patients of chronic respiratory failure in prethrombotic state

目的探讨慢性呼吸衰竭患者的血栓前状态及无创通气对其的影响。方法分别测定50例慢性呼吸衰竭患者及50例正常人的血气分析、凝血指标;把慢性呼吸衰竭患者随机分为无创通气组和常规治疗组,比较治疗前后两组血气分析、凝血指标的变化。结果慢性呼吸衰竭患者二氧化碳分压、血浆D-二聚体、纤维蛋白原、凝血酶原时间较正常人明显升高,无创通气组二氧化碳分压、血浆D-二聚体、纤维蛋白原、凝血酶原时间较常规治疗组明显降低,差异有显著性。结论慢性呼吸衰竭患者存在高凝状态,易致肺小动脉血栓形成。无创通气能显著改善血栓前状态。

Objective To investigate the influence of non - invasive ventilation on the patients of chronic respiratory failure in prethrombotic state. Methods The blood gas analysis was conducted and the blood coagulation indicators of 50 patients with chronic respiratory failure and of 50 normal patients were studied. The patients with chronic respiratory failure were randomly divided into non-invasive ventilation group and the conventional treatment group, and then the changes of blood gas analysis, blood indicators between them before and after the treatment were compared. Results In the patients with chronic respiratory failure, the pressure of carbon dioxide, plasma D-dimer, fibrinogen and the time of prothrombin were significantly higher than the normal. In the patients with non-invasive ventilation group, the carbon dioxide partial pressure, plasma D-dimer, fibrinogen, the time of prothrombin were lower than conventional the treatment group, with a significant difference. Conclusion The existence of hypercoagulability in patients with chronic respiratory failure can easily lead to pulmonary artery thrombosis. Non - invasive ventilation can significantly improve the prethrombotic state.