含左氧氟沙星序贯疗法根除幽门螺杆菌的疗效观察

Eradication of Helicobacter pylori with levofloxacin sequential therapy

目的观察由雷贝拉唑、左氧氟沙星、阿莫西林、呋喃唑酮组成的10日序贯疗法根除幽门螺杆菌(Hp)的疗效。方法将经胃镜检查确诊为慢性胃炎和消化性溃疡且Hp阳性的患者88例随机分为两组,治疗组(44例)方案为前5d给予雷贝拉唑、阿莫西林,后5d给予雷贝拉唑、左氧氟沙星、呋喃唑酮;对照组(44例)三联疗法为雷贝拉唑、阿莫西林、克拉霉素,疗程7d。比较治疗后两组患者Hp根除率。结果治疗组Hp根除率为90.9%,对照组为75.0%,两组患者Hp根除率间差异有统计学意义(P<0.05)。结论以雷贝拉唑、左氧氟沙星等组成的10日序贯疗法治疗Hp感染具有较高的根除率。

Objective To evaluate the eradication rate of ten days sequential therapy consisted of rabeprazole, amoxicillin, levofloxacin and furazolidone for Helicobaeter pylori （Hp） infection. Methods Totally 88 Hp - infected patients with peptic ulcer or chronic gastritis diagnosed by gastroscopy were enrolled. These patients were randomly divided into trial group （ n = 44 ） and control group （ n = 44 ）. Patients in trial group received rabeprazole, amoxicillin for the first 5 days, and followed by rabeprazole, levofloxacin and furazolidone for the last 5 days, and patients in control group received rabeprazole, clarithromycin and amoxicillin for 7 days. The stalus of Hp in patients of these two groups was compared after completion of treatment. Results The eradication rate of sequential therapy for ten days was 90.9% and that of control group was 75.0%. There was significant difference between these two groups （ P 〈 0.05 ）. Conclusion The 10 - day sequential therapy comprising rabeprazole and levofloxacin can achieve a higher eradication rate of lip.