佳林豪改善贫血及对维持性血液透析患者心脏结构和功能的影响

Effect of Jialinhao(rHuEPO)on Anemia and the Cardiac Structure and Function in Maintained Hemodialysis Patients

目的:观察血透病人纠正贫血与心脏结构和功能改变的相互关系。方法:采用临床前瞻性自身对照研究。血红蛋白(Hb)<90g/L的维持性血液透析患者(MHD)50例,应用彩色多普勒超声心动图测量治疗前、治疗90d后心脏结构和功能变化的指标。结果:治疗90d后贫血明显改善,心脏结构及功能的各项指标均较治疗前好转。结论:贫血是MHD患者心脏结构改变及左心功能不全的重要原因;纠正贫血可使部分慢性肾衰患者左室结构和功能稳定。

Objectives： To investigate the changes of the cardiac structure and function in hemodialysis patients, and analyze the relationship between these changes and timely treatment of anemia. Methods ： The study was a prospective trial. Fifty patients with hemoglobin（Hb） levels 〈90 g/L were enrolled in this study. All patients receive rHuEPO for 3 months. Left ventricle diastasis diameter （ LVEDD）, interventricular septum （ IVS）, posterior wall thickness （ PWTH）, left ventricle ejection fraction （ LVEF）, left ventricular mass index（LVMI） were measured by ultrasonic- cardiography. Results： The levels of Hb levels, LVEDD, IVS, PWTH, LVEF,LV- MI took a favorable turn. Conclusions： Anemia is a very important factor which influences the cardiac structure and function in CRF patients. Timely treatment of anemia can take a favorable effect on the cardiac structure and function in MHD patients.