紫杉醇联合顺铂治疗宫颈癌临床观察

The Clinical Observation of Paclitaxel and Cisplatin in the Treatment of Cervical Cancer

目的：评价和观察紫杉醇联合顺铂化疗对晚期宫颈癌的疗效及安全性。方法：对30例晚期局部宫颈癌给予TP方案化疗：用紫杉醇135mg／m^2静脉滴注持续3h，d1；顺铂7Smg／m^2静脉滴注分两天用（d1、2），21d为1周期，所有患者均至少接受3个周期化疗。结果：CR 3例（10％），PR 11例（36．67％），SD 10例（33．33％），PD 5例（16．67％），总有效率（CR＋PR）46．47％。主要毒副反应为骨髓抑制，恶心、呕吐、脱发、肌肉及关节疼痛等。结论：紫杉醇联合顺铂方案治疗晚期局部宫颈癌有较好疗效，毒副反应可以耐受。值得临床推广使用。

Objective：Evaluation and observation of paclitaxel and cisplatin chemotherapy for advanced cancer of the efficacy and safety. Methods：30 cases of locally advanced cervical cancer chemotherapy given TP,All patients received at least three cycles of chemotherapy. Results：The total effective rate （CR ＋ PR） 46.47%,The main toxicity was myelosuppression, nausea, vomiting, hair loss, muscle and joint pain. Conclusion：Paclitaxel and cisplatin in the treatment of advanced cervical cancer has a good local efficacy, toxicity can be tolerated, it is worth for clinical use.