中西药结合对猪弓形虫病的疗效研究

Effects of Integrated Chinese Herbs and Western Medicine on Swine Toxoplasmosis

[目的]评价中西药结合治疗猪弓形虫病的疗效,以提高其治愈率、降低复发率。[方法]用复方磺胺类药结合自拟抗弓形虫中药方剂对人工感染弓形虫病的猪进行治疗,检测其腹水含虫量。将感染猪病料接种小白鼠,进行动物回归试验。观察中西药结合治疗猪的临床表现并检测其血清循环抗原(CAg)水平,与中药组、西药组和对照组进行比较。[结果]中西药结合对弓形虫滋养体有100%杀灭作用。回归试验结果表明仅有1只接种脑组织的小白鼠中发现少量弓形虫。治疗猪只均未出现明显临床症状,其血清CAg峰值低于对照组且转阴速度比中药组、西药组和对照组快。[结论]中西药结合治疗猪弓形虫病具有较好的疗效。

[ Objective ] To evaluate the efficacy of integrated Chinese herbs and western medicine on the treatment of swine toxoplasmosis, in order to increase cure rate and lower recurrence rate. [ Method] Pigs artificially infected by Toxoplasma gondii were treated with compound sulfonamide and a seff-designed Chinese herbs formula, and the quantities of toxoplasma in ascites were determined. Animal regression experiment was performed after mice were inoculated with pathological samples of the pigs infected with toxoplasma. After treatment with integrated Chinese herbs and western medicine, the clinical manifestations of pigs were observed and the level of circulating antigen （CAg） in sera was detected. Curative effect indexes of integrated Chinese herbs and western medicine-treated group were compared with that of Chinese herbstreated group, western medicine-treated group and positive control group. [ Result ] All the toxoplasma trophozoites were killed by integrated and western medicine. Regression experiment results showed that toxoplasma appeared in only one mouse inoculated with brain of pig. The treated pigs have no significant clinical symptoms; the peak of serum CAg was lower than that of the positive control group and CAg became negative faster than that of Chinese herbs-treated group, western medicine-treated group and positive control group. [ Conclusion] The inte- grated Chinese herbs and western medicine has good effect on the treatment of swine toxoplasmosis.