厄贝沙坦对原发性高血压患者左心室肥厚及心率变异性的影响

Effect of irbesartan on left ventricular hypertrophy and heart rate variability in patients with essential hypertension

目的探讨厄贝沙坦对原发性高血压患者左心室肥厚(LVH)及心率变异性(HRV)的影响。方法65例原发性高血压患者,每日清晨7时口服厄贝沙坦,治疗前及治疗6个月后分别测定患者LVH及HRV。结果治疗后的左室后壁舒张末期厚度(LVPWT)、左室舒张末期内径(LVDd)、室间隔舒张末期厚度(IVST)、左室重量指数(LVMI)均比治疗前明显减少(P<0.01);与治疗前相比,相邻正常RR间期标准差(SDNN)、相邻正常RR间期差值的方差(RMSSD)、相邻正常RR间期差值大于50 ms的窦性心律占心搏总数的百分比(PNN50)、高频功率(HF)明显增加(P<0.01),而低频功率(LF)及LF/HF则明显降低(P<0.05或0.01)。结论厄贝沙坦对原发性高血压患者的LVH有显著的改善作用,对HRV有显著的扭转作用。

Objective To study the effect of irbesartan on left ventricular hypertrophy （LVH）and heart rate variability （HRV）in patients with essential hypertension （EH）. Methods Sixty-five EH patients received oral irbesartan once daily. LVH and HRV were determined before and 6 months after irbesartan treatment. Results Compared with before irbesartan treatment, standard deviation of normal to normal intervals （SDNN）, rate mean square of the differences of successive RR intervals （RMSSD）, percentage of RR intervals differing 〉 50 ms （PNN50）, and high frequency （HF） increased, while left ventricular posterior wall thickness （LVPWT）, left ventrieular diastolic dimension （LVDD）, interventricular septal thickness （ IVST）, left ventricular mass index （LVMI）, low frequency （LF） and LF/HF decreased after treatment （ P 〈 0.05 or 0.01 ）. Conclusion Irbesartan can improve LVH and HRV in Eli patients.