摘要
以四苯硼钠为电活性物质，邻苯二甲酸二丁酯为增塑剂与５％的聚氯乙烯四氢呋喃溶液混合，涂覆在离子敏感场效应晶体管（ＩＳＦＥＴ）的栅极上，制得一种对利多卡因响应的药物敏感离子场效应晶体管传感器（ＤｒｕｇＦＥＴ）。该传感器测定利多卡因的线性范围为０．０３～１０ｍｍｏｌ·Ｌ－１，斜率为５９．５ｍＶ／ｐｃ，适宜ｐＨ为２．５～６．０，检测下限为１０μｍｏｌ·Ｌ－１．用其分析盐酸利多卡因注射液含量，结果与药典方法相一致。
A kind of lidocaine drug FETS by the combination of ion sensitive field effect transistor (ISFET) and drug sensitive membrane was developed with sodium tetraphenyl borate as electric active materials,DBP as plasticizer with 5% of PVC of tetrahydrofuran solution deposited on the ISFET gate area.The sensors response to lidocaine with a slope of 59.5 mV/pc detected out the concentration ranges of 0.03~1.0 mmol·L-1 at pH ranges 2.5~6.0 with the lower detection limit of 10 μmol·L-1.The results obtained in the determination of lidocaine in injection hydrochloride agree with those by the pharmacopoeia method.
出处
《西北农业大学学报》
CSCD
北大核心
1998年第3期100-103,共4页
Journal of Northwest Sci-Tech University of Agriculture and Forestry（Natural Science Edition)
基金
陕西省教委科学基金
关键词
药物分析
利多卡因
FITS
ISFET
drug analysis,lidocaine,ion sensitive field effect transistor
