小剂量短疗程抵克立得对ADP诱导的血小板聚集性的影响
摘要
采用开放型单向序贯设计,检测了小剂量、短疗程抵克立得治疗对ADP诱导的血小板预售性的影响。方法为受试者在治疗期间每日1次服用抵克立得250mg,共治疗3周;治疗前后分别测定ADP诱导的最大血小板聚集率。结果显示,这种方法能够有效地抑制ADP诱导的血小板聚集,值得临床上进一步研究和应用。
出处
《哈尔滨医科大学学报》
CAS
1998年第4期261-264,共4页
Journal of Harbin Medical University
参考文献13
-
1Geut M,Blakeley JA,Easton JD,et al.The Canadian-American ticlopidine study(CATS)in thromboembotic stroke,Lancet,1989;1:1215.
-
2Hass WK,Easton JD,Adams HP,et al.A randomised trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high risk Patients.N Engl J Med,1989;321:501.
-
3Janzon L,Bergquist D.Boberg J,et al.Preventionof myocardial infarction and stroke in patiemts with intennittent elaudieation:effects of tiolopidive,Results from STIMS,the Swedish tiolopidine multicentre study.J Intern Med,1990;227:201.
-
4Balsano F,Rizzon P,Violi F,et al.vntiplatelet treatment with ticlopidine in unsteble argina:a controlled multicenter clinical trial.Circulation.1990;82:17.
-
5Yuan J,Li Y,Zhang M,et al.The effect of ticlopidine on platelet aggregation and hemorrheology for the aged patients with common thrombotic disorders.Chin J Phath,1992;8:463.
-
6Zheng Q.The clinical results of ticlopidine in patients with acute myocardial infarction,N Chin Med,1994;25:292.
-
7Run C,Zhang C,He Y,et al.The effects of ticlopidine in patients with stroke.Nat Med J Chin,1991;71:408.
-
8Roth GJ,Stanford N,Majerus PW.Acatyation of prostaglandin synthase by aspinim. Proc Natl Acad Sci,1975;72:3073.
-
9Dewitt DC,Smith WL.Primary structure of prostaglandin G/H synthase from aheep vesicular gland detennined from the complementary DNA sequence.Proc Natl Acad Sci,1988;85:1412.
-
10Funk CD,Funk LB,Kennedy ME,et al.Human platelet erythroleukemia cell prostaglandin C/H synthase:cDNA cloning,expression,and gene chromosomal as signment,FASEB J,1991;5:2304.
-
1李益明,段文澜,李吟遒,沈一鸣,杨秀芳,朱禧星.抵克立得对2型糖尿病患者血液流变学和血小板聚集的影响[J].中国新药杂志,1999,8(2):111-113. 被引量:4
-
2张纪军.异舒吉联合抵克立得、肝素治疗不稳定心绞痛的临床观察[J].医学文选,2003,22(5):651-652.
-
3盛琪.抵克立得引致过敏性反应3例[J].皮肤病与性病,2002,24(1):43-44.
-
4吕海燕,孙宗娟,戎娟.抵克立得抗血小板作用及对血液学异常改变的观察[J].药学与临床研究,1999,14(3):49-49. 被引量:1
-
5李宗友,刘亚军,蒋东生.抵克立得预防TIA复发164例疗效观察[J].中原医刊,1999,26(5):38-38.
-
6刘雅,谢雪,黄斌,陆佩芳.抵克立得对糖尿病肾病的作用[J].辽宁实用糖尿病杂志,2000,2(2):26-27.
-
7陈文备,占晓玲.抵克立得降低脑梗塞患者血粘度疗效观察[J].浙江预防医学,2002,14(12):65-65.
-
8张振华,刘伟娜,付炎,郭毅,阎宏伟,朱孝芹.抵克立得片中盐酸噻氯匹定的定量分析研究[J].分析科学学报,2001,17(3):263-263.
-
9王丽.口服抵克立得致粒细胞减少2例[J].现代中西医结合杂志,2002,11(2). 被引量:2
-
10李进禧.抗血小板聚集新药—抵克立得[J].医师进修杂志,1992,15(11):41-42.