HPLC法测定复方银翘氨酚维C片中对乙酰氨基酚的含量

Determination of Paracetamol in Compound Yinqiao and Paracetamol and Chlorphenamine Maleate and Vitamin C Tablet by HPLC

目的:建立HPLC法测定复方银翘氨酚维C片对乙酰氨基酚的含量。方法:色谱柱:大连依利特Hypersil ODS,流动相为甲醇-水(20∶80),检测波长为249 nm。结果:线性范围为2.0～10.0 mg.L-1(R=0.999 7),回收率良好,RSD=0.96%。结论:本法简便、准确、重现性好,可适用该制剂的含量测定。

Objective： To ectablish an HPLC method for determination of Paracetamol in Compound Yinqiao and Paracetamol and Chlorphenamine Maleate and Vitamin C Tablet. Methods： Dalian Elite Hypersil ODS column was used with methanol-water （20： 80） as mobile phase. Content was detected at the wavelength of 249 nm. Results： The linear range was 6 - 14 mg·L^-1 （ R = 0. 999 7 ）. The recovery was very good with RSD 0. 96%. Conclusion：It is a simple, accurate and repeatable method and could be used for determination of paracetamol in Compound Yinqiao and Paracetamol and Chlorphenamine Maleate and Vitamin C Tablet.