摘要
选择中度以上慢性肝炎和早期肝硬化患者120例，分为治疗组和对照组各60例。治疗组采用软肝冲剂治疗，对照组以干扰素治疗，疗程均为3个月，观察血清透明质酸（HA）、Ⅲ型前胶原肽（PⅢP）、Ⅳ型胶原（C-Ⅳ）、板层素（LN）等肝纤维化指标，以及肝功能和病毒复制指标。结果治疗组HA、C-Ⅳ、LN、ALT和γ-Glb明显下降，与对照组比较有显著性差异（P＜0．05），HBeAg和HBVDNA阴转率略低于对照组。结果表明软肝冲剂治疗肝纤维化作用比较全面，且在一定程度上优于干扰素。
120 patients with over middle degree chronic hepatitis and early cirrhosis weredivided therapeutic group (TG) and control group (CG), including 60 cases each. The TH wastreated by ruangan granule (RG) and the CG by interferon for three months. The indexes ofhepatic fibrosis,such as HA, P Ⅲ P C- Ⅳ, LN and virus duplication,liver function were detected.The results showed that HA, C-Ⅳ, LN, ALT and γ-Glb in TG were obviously decreased. Therewas significant difference among the TG and CG (P <0. 05～0. 01). Negative ratio of HBeAgand HBV DNA in TG were slightly lower than those of the CG.
基金
广东深圳市科委资助!92043
关键词
肝纤维化
软肝冲剂
干扰素
药理
hepatic fibrosis, ruangan granule, interferon
