异丙酚联合舒芬太尼在无痛胃镜检查中的应用

Propofol combined with sufentanil in painless gastroscopy

目的研究异丙酚联合舒芬太尼在胃镜检查中麻醉效果及安全性。方法60例行胃镜检查的患者按随机数字法分为对照组（n=30）和麻醉组（n=30）。对照组静脉注射芬太尼1μg／kg、咪达唑仑1mg和异丙酚（1．5mg／kg）行麻醉诱导；麻醉组静脉注射舒芬太尼0．1μg／kg、咪唑安定（1mg）和异丙酚（1．5mg／kg）行麻醉诱导；2组患者意识消失后进行胃镜检查。2组患者在胃镜检查中均观察血压、心率、血氧饱和度、清醒时间、呼吸暂停、低氧血症、心动过缓、低血压等术中并发症的发生率。结果麻醉组心率和血压与对照组相比，差异无统计学意义（P〉0．05）；2组血氧饱和度和苏醒时间差异无统计学意义（均P〉0．05）。对照组呼吸暂停发生率明显高于麻醉组（P〈0．05）；而麻醉组低氧血症、心动过缓、低血压发生率和苏醒时间与对照组比较，差异无统计学意义（均P〉0．05）。结论异丙酚联合舒芬太尼进行胃镜检查是一种安全、有效、无痛苦的胃镜检查方法。

Objective To research the effect and safety of propofol anesthesia with sufentanil during gastroscopy. Methods Sixty patients were randomly divided into two groups ： control group （ n = 30） and anesthesia group（ n = 30）. In control group , Fentanyl 1 ug/kg, Midazolam 1 mg, propofol 1.5 mg/kg were given intravenously slowly. In anesthesia group , sufentanil （0.1 ug/kg）, Midazolam 1 mg,propofol 1.5 mg/kg were given intravenously slowly. The patients were performed gastroscopy in unconscious status. BP, HR and SpO2, sober time, apnea, hypoxemia, bradycardia and hypotension during operation were observed. Results HR and BP were lower in anesthesia group than those in control group （ P 〈 0.05 ）. There was not remarkable difference in SpO2 and sober times （ P 〉 0.05 ） between both groups. Compared with control group, apnea increased in anesthesia group. There was not remarkable difference of hypoxemia, bradycardia, low blood pressure, recovery time （ P 〉 0.05 ） between both groups. Conclusion Gastroscopy can be achieved successfully with propofol combined with sufentanil.