晚发型帕金森病经颅超声的表现

Transcranial sonography in late-onset Parkinson's disease

目的研究晚发型帕金森病(LOPD)患者经颅超声(transcranial sonography,TCS)的表现。方法招募符合入选标准的LOPD患者和年龄匹配的正常对照者,分别进行TCS检测。对于检测成功的受试者的黑质异常信号进行半定量分级测评,同时测定第三脑室的宽度。结果TCS检查在老年女性中成功率很低。两组间黑质强回声分级有极强的显著性差异。黑质强回声分级与患者的年龄、发病年龄、病程及病情严重程度不相关。两组间第三脑室宽度无显著性差异。结论TCS检查在老年女性中应用受限制。明显的黑质异常强回声可能是LOPD患者的特征性表现。其强回声分级与患者年龄、发病年龄、病程及病情严重程度不相关。晚发型帕金森病患者组无明显第三脑室增宽。

Objective To investigate the characteristic features of transcranial sonography （ TCS ） in patients with late-onset Parkinson＇ s disease （LOPD）. Methods We enlisted some LOPD patients and age-matched normal controls according to special criteria,and detected them by TCS. The obtained images of the subjects whose images could offer analyzing substantia nigra （SN） hyperechogenicity with sufficient resolution were evaluated. We used semi-qualitative estimation criteria to assess SN hyperechogenicity and also measured the widths of the third ventricles. Results There was a high rate of recording failure of the SN in older females. Significant SN hyperechogenicity was observed in LOPD patients group. There was no correlation between the degree of SN hypereehogenicity and patients＇ age, onset age, duration of illness, and the severity of condition. There was no significant differenee of the widths of the third ventricles between groups. Conclusions The recording failure in aged females may limit the clinical potential of TCS. SN hyperechogenicity maybe the characteristic features in LOPD patients. There was no correlation between the degree of SN hyperechogenicity and patients＇ age, onset age, duration of illness, and the severity of condition. The widths of the third ventricles in LOPD patients group were not increased significantly.