平阳霉素联合地塞米松治疗婴幼儿颌面部静脉-微静脉畸形46例疗效分析

Pinyangmycin and Dexamethasone Combined Treatment for Venous-venular Malformation to 46 Cases in the Maxillofacial Regions of Infants

目的探讨平阳毒素和地塞米松联合瘤腔注射治疗婴幼儿颌面部静脉-微静脉畸形的疗效。方法将平阳霉素4～8mg、地塞米松3～5mg、2%利多卡因2mL、生理盐水2mL混合溶解后行瘤体内注射至肿胀发白为宜,注射剂量0.2～0.3mg/kg,总量不超过8mg。2～3周注射1次,3～5次1个疗程。结果本组治愈22例(47.8%),基本治愈19例(41.3%),好转5例(10.9%),总有效率100.0%。术后随访12～24个月,无1例复发。结论平阳霉素联合地塞米松注射治疗婴幼儿颌面部静脉-微静脉畸形是一种简便易行、安全可靠的治疗方法。

Objective to investigate pinyangmycin and dexamethasone combined treatment for venous-venular malformation in the maxillofacial regions of infants. Methods A mixture solution was prepared with 4-8 mg of pinyangmycin, 2 mL of normal saline, 3 - 5 mg dexamethason and 2 mL of 2 % lidocaine. The mixture solution was injected into the hemangioma to the extent that the hemangioma began to swell and turned pale. The therapeutic dose ranged from 0. 2 to 0.3 mg/kg,and the maximum was 8 mg. The patients were treated every 2 to 3 weeks, 3 to 5 times in total. Results All cases were followed up from 12 to 24 months. The total effectiveness rate was 100.0% ,and complete reponsed 22 cases（47.8%）,partial reponsed 19 cases（41.3%）, improvement 5 cases （ 10. 9 %）. Conclusion Pinyangmycin and dexamethasone combined treatment is simple,safe and effective for venous-venular malformation in the maxillofacial regions of infants.