鹿蹄橐吾化学成分研究

Studies on the Chemical Constituents of Ligularia hodgsonii

目的:研究鹿蹄橐吾的化学成分,鉴定化合物结构。方法:通过硅胶柱色谱,并运用硅胶薄层制备以及凝胶柱色谱的方法分离纯化化合物,利用现代分析技术解析化合物结构。结果:分离得到了4个化合物:槲皮素(Ⅰ),(E)-3-(2-羟基-4-甲氧基苯基)-2-丙烯酸(Ⅱ),(E)-3-(2,4-二羟基苯基)-2-丙烯酸(Ⅲ),(S)-3-羟基-3-苯基丙酸(Ⅳ)。结论:化合物(Ⅰ),(Ⅱ),(Ⅲ)和(Ⅳ)均为首次从该植物中分离得到。

Objective：To study chemical components in Ligularia hodgsonii. Methods：Compounds were isolated and purified by normal Column Chromatography, Paper Thin Layer Chromatography and Sephadex Chromatography. The chemical structures of compounds were mainly elucidated by modern analytical technology. Results：Four compounds were isolated from Ligularia hodgsonii., Quercetin （ Ⅰ ）, （E）-3-（2- hydroxy-4-methoxyphenyl）-2-acrylic acid （ Ⅱ ）, （E）-3-（2,4-dihydroxyphenyl）-2-acrylic acid （ Ⅲ ）, （S）-3- hydroxy-3-phenylpropanoic acid （Ⅳ）. Conclusion： Compounds （ Ⅰ ）, （ Ⅱ）, （Ⅲ） and （Ⅳ） were all isolated from Ligularia hodgsonii.for the first time.