添加人绝经促性腺激素对IVF-ET术中卵巢反应不良患者的意义

Effects of Human Menopausal Gonadotropin(HMG) supplementation in low ovary responders undergoing in vitro fertilization-embryo transfer(IVF-ET) cycles

目的：探讨对体外受精胚胎移植（IVF—ET）术中卵巢反应不良患者添加人绝经促性腺激素（HMG）的意义。方法：对照组47例患者单纯使用rFSH，实验组41例患者在前3～6天使用rFSH，后根据患者卵巢反应情况加用HMG。对入选患者的一般情况、促排卵过程中卵巢反应性指标和IVF—ET结果进行统计分析。结果：实验组获卵数、成熟卵数、受精个数均明显高于对照组，差异有显著性意义（P〈0．05）；而两组患者的Gn使用总量、HCG日E2和LH值、2PN个数、受精率、卵裂率、优良胚胎数、冷冻胚胎数及妊娠率差异均无显著性意义。结论：添加HMG可提高IVF—ET术中卵巢反应不良患者成熟卵子获得数和降低费用。

Objective： To explore the effectiveness of administering Human Menopausal Gonadotropin （HMG） in low ovary responders undergoing in Vitro fertilization - embryo transfer （ IVF - ET） cycles. Methods： Eighty eight poor ovary responders who suffered IVF - ET were prospectively randomized into two groups. The control group （ n = 47 ） were treated with rFSH only. The study group （ n = 41 ） received a supplementation with a daily HMG after three to six days of utilizing rFSH. A statistical analysis was carried out for the assessment of their ovary response and clinical pregnancy rate. Results： The average number of oocytes retrieved, oocytes either in mature or in fertilization in the study group were significantly more than those in the control group （P 〈 0. 05 ） . There was no significant difference in the total injected dosage, the serum E2 and LH levels on the day of hCG, fertilization rates, cleavage rates, good embryos, frozen embryos and implantation rates between two groups. Conclusion： The addition of HMG during controlled ovarian stimulation in low responders for IVF -ET can not only improve the number of mature oocytes retrieved, but also drastically decrease costing.