卡维地洛治疗慢性充血性心力衰竭疗效观察

The Clinical Observation of Curative Effect of Carvedilol for Chronic Congestive Heart Failure

目的:探讨卡维地洛对慢性充血性心力衰竭(Chronic Congestive Heart Failure,CHF)的疗效和安全性。方法:将71例慢性充血性心力衰竭患者随机分为卡维地洛组(治疗组)和常规治疗组(对照组),对比两组治疗前、6个月后左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)、心率、血压和心功能变化情况,观察卡维地洛的疗效和安全性。结果:卡维地洛组左室舒张末期内径、左室收缩末期内径、血压降低、心率减慢、左室射血分数、心功能分级明显提高,与对照组比较差异有显著性(P<0.05)。结论:卡维地洛治疗慢性充血性心力衰竭能改善心功能,改善左室重塑,使用安全,疗效显著。

Objective：To investigate the curative effect and safety of earvedilol treatment on chronic congestive heart failure （CHF）. Methods： 71 cases with CHF were randomly divided into two groups： the earvedilol treatment group （treated group） and the conventional treatment group （control group）, comparing changes of the left ventricular enddiastolic diameter（LVEDD）, left ventricular end-systolic diameter （LVESD）, left ventricular ejection fraction （LVEF）, heart rate, blood pressure, cardiac function in two groups between before and after six-months＇ treatment, in order to observe the curative effect and safety of earvedilol. Results： The LVEDD, LVESD, blood pressure and heart rate reduces, and LVEF, cardiac function classification raised significantly. And the difference compared to control group had significance（P〈0. 05）. Conclusion： The earvedilol improve the cardiac function, enhance the remodeling of left ventricular,and it is safe and effective.