期刊文献+

一种实用的结直肠癌新辅助化疗 被引量:1

下载PDF
导出
摘要 目的:探讨结直肠癌新辅助化疗的疗效。方法:选择结直肠癌52例,分两组,治疗组26例按CF200mg/m^2静滴,5-FU 400mg/m^2静注,5-FU 2 400-3 600mg/m^2,加入Baxter泵中48h维持静滴术前化疗1次,1周内手术,术后对DukeB期以上按FOLFOX-6方案:Oxaliplatin 135mg/m^2静滴3h,然后CF200mg/m^2静滴2h,然后5-FU400mg/m^2静注,然后5-FU2 400-3 600mg/m^2加入Baxter泵中48h维持静滴,14d重复,共化疗4次,对照组不做术前化疗,术后化疗一样,对两组治疗病人按WHO标准统计CP、PR、SD、PD、和毒副反应进行综合评价。结果:治疗组术前化疗一次CEA、CA19-9均有一定程度下降,毒副反应轻,随访2年,2年的无瘤生存率92.30%,对照组84.62%。结论:该方案可提高结直肠癌的疗效而不增加住院时间和医疗费用。
作者 肖俊
出处 《医学理论与实践》 2009年第7期821-822,共2页 The Journal of Medical Theory and Practice
  • 相关文献

参考文献3

二级参考文献15

  • 1曹建国,廖端芳,陈剑雄,朱炳阳,张德菊,唐小卿.琼脂培养MTT法测定混合培养HeLa细胞和人胚肺纤维母细胞药物敏感性[J].中国肿瘤临床,1995,22(7):495-499. 被引量:21
  • 2Hortobaggi GN. Comprehensive management of locally advanced breast cancer. Cancer, 1990,66:1387-1 390
  • 3Tsujihashi H, Nakanishi A, Matsude H et al . Cell proliferation of human bladder tumors, determined by BRDURD and Ki-67 immunostaining. J Ural,2001,145(2) :846-849
  • 4Barletta, Marzullo F, Pellcchia A et al . DNA flowcytometry,P53 level and proliferative cell nuclearantigen in human colon dysplasyive, precancerous and cancerous tissue. Anticancer Res, 1998,18(4): 1 167-1 171
  • 5Meyn RE, Stephens LC, Hunter NR et al . Induction of apoptosis in murine tumor by cyclophosphamide. Cancer Chemother Pharmacol, 2000,33: 410-414
  • 6Bhalla K, Harris WB. Molecular and biologie determinants of neoadjuvant chemotherapy of locoregional breast cancer. Sem Onco, 1998,252 (suppl3): 19-24
  • 7姜泊.细胞凋亡基础与临床[M].北京:人民军医出版社,1996.116-117.
  • 8Kaufmann SH, Desnoyers S, Ottaviano Y, et al.Specific proteolytic cleavage of poly (ADP-rbose) polymerase: an early marker of claemotherapy-induced apoptosis [ J ], Cancer Res,1993,53(17) :3976 - 3985.
  • 9Johnstone RW, Cretney E, Smyth MJ. P- glycoprotein protects lemnemia ceils against caspase-dependent, but not caspase - independent cell death[J]. Blood, 1999,93(3) : 1075 - 1085.
  • 10Sadanand V, Kankesan J, Yusuf A. Effect of PSC 833, a potent inhibitor of P - glyeoprotein, on the growth of astroeytoma cells in vitro [ J ]. Cancer Lett, 2003,198 ( 1 ) : 21 -27.

共引文献69

同被引文献8

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部