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癌症新策略—let-7 microRNA家族 被引量:6

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摘要 microRNA是近年发现的一类单链小分子RNA,对它的研究已成为一个新的热点。let-7基因编码的stRNA则被认为是miRNA的代表,最近的研究发现,let-7 miRNA在细胞内影响着基因的表达调控,在疾病发生中起着及极重要的作用,尤其是在肿瘤的发展过程中,let-7 miRNA扮演着不可替代的角色。本文介绍let-7 miRNA在肿瘤中作用机制的最新研究进展。
作者 张强 李明远
出处 《西部医学》 2009年第7期1210-1212,共3页 Medical Journal of West China
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参考文献10

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同被引文献88

  • 1杨玲,李连弟,陈育德,Donald Maxwell Parkin.中国肺癌死亡趋势分析及发病、死亡的估计与预测[J].中国肺癌杂志,2005,8(4):274-278. 被引量:168
  • 2Oak SR, Murray L, Herath A, et al. A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis. PLoS One,2011,6 :e21253.
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  • 7Liu G, Friggeri A, Yang Y,et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med, 2010,207 : 1589-1597.
  • 8Cushing L, Kuang PP, Qian J, et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol, 2011,45:287-294.
  • 9Pottier N, Maurin T, Chevalier B, et al. Identification of keratinoeyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenehymal interactions. PLoS One,2009,4 : e6718.
  • 10周海燕,李勇.miR-155研究进展.现代生物医学研究进展2009,9:4778-4782.

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