原因不明习惯性流产与HLA-G的相关性研究进展

The Advance in the Association between Recurrent Spontaneous Abortion and Human LeukocyteAntigen-G

人类白细胞抗原G（HLA—G）是人类白细胞抗原I类中的非经典抗原，主要表达在人类早期胎盘绒毛外细胞滋养层上，在妊娠免疫耐受建立中起重要作用。近几年来的研究结果表明，HLA-G与原因不明习惯性流产的发生发展密切相关。在此就HLA的分子生物学特点、HLA—G的组织分布、HLA—G基因与表达、HLA—G基因多态性及其与原因不明习惯性流产的关系等方面予以综述。

Human leukocyte antigen-G （HLA-G） is one of the non-classical class I human leukocyte antigen ,which are expressed mainly in the trophoblast cells outside the placental villi in the early pregnancy. They play an important role in the establishment of immune tolerance in pregnancy. In the passed decade, many studies have shown that HLA-G is associated with the recurrent spontaneous abortion. This review will discuss the molecular biological characteristics of HLA, the tissue distribution of HLA-G, the HLA-G gene and expression,the HLA-G gene polymorphism and the association with the recurrent spontaneous abortion.