6The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med, 1993,329 (14) :977-986.
7Shichiri M, Kishikawa H, Ohkubo Y, et al. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic pa- tients. Diabetes Care ,2000,23.
8Suppl 2 : B21-B29. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35 ) : prospective observational study. BMJ, 2000, 321 (7258) :405-412.
9Isoda K, Young JL, Zirlik A, et al. Mefformin inhibits proinflamma- tory responses and nuclear factor-kappaB in human vascular wall cells. Arterioscler Thromb Vasc Biol,2006,26(3) :611-617.
10Butler AE ,Janson J, Bonner-Weir S, et al. Beta-cell deficit and in- creased beta-cell apoptosis in humans with type 2 diabetes. Diabe- tes,2003,52( 1 ) :102-110.
