阿奇霉素治疗儿童社区获得性细菌性肺炎临床观察

Azithromycin in treament of children with community-acquired bacterial pneumonia

目的观察阿奇霉素治疗轻、中度儿童社区获得性细菌性肺炎的疗效和安全性。方法74例社区获得性肺炎患儿随机分为两组，治疗组34例口服阿奇霉素每日5mg／kg，10k／d；连续5～7d；对照组40例予阿莫西林／克拉维酸30mg／kg静脉滴注，2次／d，连续应用5—7d。结果治疗组总有效率为85．3％，对照组总有效率80．0％，两组总有效率比较差异无统计学意义（r=0．36，P〉0．05）。结论阿奇霉素是治疗社区获得性细菌性肺炎安全、有效的药物。

Objective To investigate the efficacy and safety of azithromyci in treatment of children with mild and middle community - acquired bacterial pneumonia. Methods Seventy - four patients were randomly divided into the treatment group and the control group. The patients of the treatment group（n =34） received the treatment with oral azithromycin in a dose of 5mg/kg,one time daily for 5 -Tdays;the patients of the control group （n =40） received the treatment with intravenous drip of augmentin in a dose of 30mg/kg,two time daily for 5 ~ 7 days. Results A sat- isfactory clinical response （ the cured plus the improved） was achieved at the rate of 85.3% and 80.0% repectively in the treatment with azithromycin and augmentin （X2 = 0. 36, P 〉 0. 05 ）. Conclusion These results indicate that azithromycin is effective and safe in the treatment of children with mild and middle community - acquired bacterial pneumonia.