长托宁联合血液灌流治疗急性重度有机磷农药中毒的临床分析

Clinical observation of combined use of penehyclidine hydrochloride injection and hemoperfusion for acute organophosphorus pesticide poisoning

目的观察长托宁联合血液灌流治疗急性重度有机磷农药中毒（AOPP）的疗效。方法43例经口服重度AOPP患者随机分为2组，阿托品联合血液灌流组（A组，21例）和长托宁联合血液灌流组（B组，22例），通过观察患者的给药次数、总药量、血液灌流次数、治愈率、平均住院天数及不良反应发生率比较两种方法的临床疗效。结果B组给药次数、总药量、血液灌流次数、不良反应、平均住院天数均明显少于A组（P〈0．05）。结论长托宁联合血液灌流在抢救治疗急性重度有机磷农药中毒的疗效优于阿托品联合血液灌流，且副作用更少。

Objective To investigate the treatment effect of the combination of penehyclidine hydrochloride injection and hemoperfusion for acute organophosphorus pesticide poisoning （AOPP）. Methods Forty - throe pa- tients with AOPP were randomly divided into two groups. They were atropine combined with hemoperfusion group （ A group, 21 cases ） , penehyclidine hydrochloride injection combined with Hemoperfusion group （B group, 22 cases） , the treatment effects of two groups were estimated by observing the times of taking the medicine , the total amount of taking the medicine, the times of hemoperfusion, the rate of cure ,the average days of treatment and the occurrence rate of adverse reaction. Results The times of taking the medicine , the total amount of taking the medicine, the times of hemoperfusion, the average days of treatment and the adverse reaction of B group were less than that of A group（ P 〈 0. 05 ）. Conclusion The treatment effect of penehyelidine hydrocldoride injection combined with be- moperfusion for AOPP is better than that of atropine combined with hemoperfusion, and the adverse reaction is less.