罗红霉素对慢性阻塞性肺疾病急性加重期患者氧化/抗氧化失衡的影响

The role of roxithromycin in oxidant/antioxidant imbanlance in patients with acute exacerbations of chronic obstructive pul- monary disease

目的观察慢性阻塞性肺疾病(COPD)急性加重期患者血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性及丙二醛(MDA)含量变化,探讨COPD急性加重期患者氧化/抗氧化失衡情况及罗红霉素对其的影响。方法30例健康体检者(对照组,A组),30例COPD急性加重期患者常规治疗组(B组)和30例COPD急性加重期患者常规加罗红霉素(RXM)治疗组(C组)于发病初及治疗4周后检测肺功能,测定血清SOD、CAT活性及MDA含量。结果与正常体检者及C组治疗后比较,COPD急性加重期患者血清SOD及CAT均下降,差异有统计学意义;MDA升高差异有统计学意义。且SOD、CAT与FEV1/FVC呈显著正相关(r分别为0.631,0.621,P均<0.01),MDA与FEV1/FVC呈显著负相关(r=-0.438,P<0.01)。结论COPD急性加重期患者存在氧化/抗氧化失衡,罗红霉素通过调节COPD急性加重期者氧化/抗氧化失衡而减轻气流受限,改善肺功能。

Objcetive To observe the change of serum superoxide dismutase （SOD）,catalase（CAT） and malondialdehyde（MDA） in patients with acute exacerbations of chronic obstructive pulmonary disease（COPD） and to explore their imbalance between oxidant and antioxidant and to evaluate the therapeutic effects of Roxithromycin （RXM） on them.Methods Serum SOD,CAT,MDA and physiologic indexes of pulmonary function tests were measured in 30 healthy subjects （group A）,30 patients with acute exacerbations of COPD before and after common treatment （group B）,30 patients with acute exacerbations of COPD before and after common add oral administration of RXM （group C） respectively.Results The patients with acute exacerbations of COPD had a lower serum SOD,CAT and a higher serum MDA than that of the healthy subjects and after treatment of group C, there were significantly difference among them. Moreover, SOD and CAT were significantly positive correlated with FEV1/FVC （r=0.631,0.621, all P〈0.01 ）, MDA was signifi- cantly negative correlated with FEV1/FVC（r=-0.438,P〈0.01 ）.Conclusion There is oxidant/antioxidant imbanlanee in patients with acute exacerbations of COPD, RXM might regulate their oxidant/antioxidant imbanlance and improve pulmonary function.