结直肠癌COX-2、MMP-7和MVD的表达与预后

Expressions of COX-2,MMP-7,MVD in colorectal carcinoma and their correlations with prognosis

目的探讨环氧化酶-2、基质金属蛋白酶-7和微血管密度在结直肠癌中的表达及其与临床病理及预后的关系。方法应用免疫组织化学法(SP法)检测62例结直肠癌COX-2、MMP-7和MVD的表达,并分析其与结直肠癌组织学分级、浸润深度、淋巴结、远处转移、Dukes分期及预后的关系。结果COX-2和MMP-7在结直肠癌组织中表达的阳性率显著高于正常组织(P<0.05)。两者的表达与淋巴结转移、Dukes分期、浸润深度相关(P<0.05)。MVD的表达与淋巴结、远处转移、Dukes分期、组织学分级相关(P<0.05)。COX-2、MMP-7的表达与预后相关。结论COX-2、MMP-7和MVD的表达可作为判断结直肠癌临床病理特征和预后的可靠指标之一。

Objective To investigate the expressions of COX-2,MMP-7 and MVD in colorectal carcinoma and their relationship with clinicopathological factors and prognosis.Methods Immunohistochemical methods were used to detect the expression of COX-2, MMP-7 and MVD in 62 case of colorectal carcinomas.The relationship between expressions of COX- 2,MMP-7 and MVD and histological grade, invasive depth,lymph node and distant metastasis, Dukes staging and prognosis were analyzed.Results The positive rate of the expressions of COX-2 and MMP - 7 was significantly higher in colorectal cancer tissues than in normal tissues （P〈0.05）. The expressions of COX-2 and MMP-7 were correlated to lymph node metastasis, Dukes grade of carcinoma and depth of invasion （ P〈 0.05）. The expression of MVD was correlated to lymph node metastasis and distant metastasis, Dukes staging,histological grade. The expressions of COX-2 and MMP-7 were correlated to prognosis. Conclusion The expressions of COX 2,MMP-7 and MVD may be a valuable indictor for assessing clinicopathological factors and prognosis.