海马突触传递长时程增强效应中的蛋白激酶

PROTEIN KINASES INVOLVED IN THE EXPRESSION OFHIPPOCAMPAL LONG-TERM POTENTIATION

对海马突触传递长时程增强效应的研究已取得许多重要进展，其中包括发现很多蛋白激酶的参与。近年来由于转基因和基因打靶等分子生物学实验手段的应用，ＰＫＣ、ＣａＭＫＩＩ和ＰＫＡ等多种蛋白激酶的同功酶或其不同亚单位在ＬＴＰ中的作用已在相应的变异小鼠上得到直接证实。文章概述了这些目前被认为参与了海马突触传递长时程增强过程的蛋白激酶及其作用。

Many protein kinases may play important roles in the expression or maintenance of hippocampal long-term potenitation (LTP). With gene targeting or transgenic technology, the involvement of some isoforms of PKC, CaMK II, PKA, and their subunits has been directly ,confirmed in the mutant mice which were deficient in the corresponding genes. This paper briefly reviews these protein kinases involved in the hippocampal LTP