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CGI-100基因在苦参碱诱导K562细胞分化和凋亡中的作用研究 被引量：3

The effects of matrine on CGI-100 expression in K562 cells
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摘要 目的了解功能未知的CGI-100基因在苦参碱诱导K562细胞分化和凋亡中的作用研究。方法利用反转录-聚合酶链反应(RT-PCR)检测苦参碱作用前后K562细胞中CGI-100基因的表达情况。结果在苦参碱作用K562细胞后CGI-100基因表达下调。结论不同浓度不同作用时间下苦参碱能使K562细胞中CGI-100基因表达下降。 Objective This study was aimed to explore the expression level of the unknown CGI-100 gene in human leukemia K562 cells treated with matrine. Methods The expression distinction of CGI-100 was evaluated by RT-PCR in K562 cells before and after being treated with matrine. Results The expression level of CGI-100 decreased in K562 cells treated with matrine. Conclusion In conclusion, the expression of CGI-100 mRNA decreased in a dose and time-dependent manner in the K562 cells treated with matrine.
作者 黄凤霞 曹励民 张彦
机构地区 西安医学院 重庆医科大学
出处 《实用医技杂志》 2009年第7期514-516,共3页 Journal of Practical Medical Techniques
关键词 苦参碱 白血病 K562细胞 Matrine leukemia K562 cells
分类号 R285 [医药卫生—中药学]
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  • 1Tabilio A, Pelicci PG, Vinci G, et al. Myeloid and megakaryocytic properties of K562 cell lines. Cancer Res,1983,43:4569-4574.
  • 2Zhang Y, Jiang JK, Liu XS, et al. Differentiation and apoptosis in K562 erythroleukemia cell induced by matrine .Natural Medicine, 1998,52:295-299.
  • 3Hideshima T, Chauhan D, Hayashi T, et al. Proteasome inhibitor PS-341 abrogate IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma. Oncogene, 2003, 22:8386-8393.
  • 4Navarro V, Vincent JP, Mazella J. Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line. Biochem Biophys Res Commun, 2002,298:760-764.
  • 5Persaud-Sawin DA, VanDongen A, Boustany RM. Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis. Hum Mol Genet, 2002,11:2129-2142.
  • 6Kiefer MC, Brauer MJ, Powers VC, et al. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature, 1995,374:736-739.

共引文献17

同被引文献39

  • 1侯周华,谭德明,谢玉桃,鲁猛厚,谢建萍,刘国珍,汪玲.苦参碱治疗慢性乙型肝炎的临床研究[J].实用预防医学,2005,12(4):824-826. 被引量：6
  • 2李贵海,王玫,孙付军,王学荣,李晓晶,尹格平.苦参碱逆转小鼠S_(180)肿瘤细胞获得性多药耐药基因相关表达产物过度表达的研究[J].中药材,2006,29(1):40-42. 被引量：19
  • 3Dai Z J, Gao J, Ji Z Z, et al.Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3[J].J Ethnapharmacol, 2009, 123(1): 91-96.
  • 4Jiang H, Hou C, Zhang S, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562eells[J].EurJPharmacol, 2007, 559(2-3): 98-108.
  • 5Li L Q, Li X L, Wang L, et al. Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells[J].Cell Physiol Biochem, 2012, 30(3): 631-641.
  • 6Cao W, Li X Q, Wang X, et al.Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels[J].Int J BiolMaeromol, 2010, 46(1): 115-122.
  • 7Zhang Y H, Yang X L, Zhang P, et al.Cytotoxic alkaloids from the bulbs of Fritillariahupehensis[J].ChemBiodivers, 2008, 5(2):259-266.
  • 8Shen S, Li G, Huang J, et al.Steroidal saponins from Fritillaria pallidiflora Schrenk[J].Fitoterapia, 2012, 83(4): 785-794.
  • 9Rasul A, Yu B, Yang L F, et al.Induction of mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Nor-kurarinone isolated from Sophora flavescens[J].Asian Pac J CancerPrev, 2011, 12(10): 2499-2504.
  • 10Ling Q, Xu X, Wei X, et al.Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c[J].J Exp Clin Cancer Res, 2011, 30(1): 66.

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实用医技杂志
2009年 第7期

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