巴曲抗栓酶与氟桂利嗪治疗眩晕的疗效观察

Curative Effect Observation of Batroxobin and Flunarizine in Treating Patients with Dizziness

目的比较巴曲抗栓酶与氟桂利嗪治疗眩晕的疗效及安全性。方法83例眩晕病人分为两组,巴曲抗栓酶组42例,在常规输注肌苷和维生素C基础上,给予巴曲抗栓酶治疗;氟桂利嗪组41例,给氟桂利嗪片治疗。均于入组前及治疗2周后对眩晕强度、频度和持续时间进行定量评价及统计学处理。结果两组治疗2周后,眩晕3项指标均明显改善(P<0.01),巴曲抗栓酶组眩晕强度及频度的改善较氟桂利嗪组更显著(P<0.01)。巴曲抗栓酶不良反应少,而氟桂利嗪不良反应较多,并有因不良反应重而停药者。结论巴曲抗栓酶治疗眩晕的疗效和安全性均优于氟桂利嗪。

Objective To compare the curative effect and safety of batroxobin and flunarizine in treating patients with dizzi- ness. Methods 83 cases with dizziness were divided into 2 groups ： batroxobin group （ n = 42 ） and flunarizine group （ n = 41 ） ; batroxobin was applied to the patients in batroxobin group besides the routine infusion of inosine and vitamin C ; flunarizine pills were given to the patients in flunarizine group; dizziness intensity, frequency and duration of the patients in beth groups before treatment and 2 weeks after treatment were quantitatively evaluated and statistically analyzed. Results 2 weeks after treatment, the 3 dizziness index of the patients in both groups were improved obviously I P 〈 0.01 ）, dizziness intensity and frequency in batroxobin group were improved even greater than those in flunarizine group （ P 〈0. 01 ）, batroxobin was of less side effects than flunarizine which sometimes caused administration stop because of severe side effect. Conclusions The effect and safety of batrexobin are superior to those of flunarizine in treating dizziness.