马来酸咪哒唑仑治疗失眠症临床对照研究

Clinical Comparative Study of Midazolam Maleate in Treating Patients with Insomnia

目的了解马来酸咪哒唑仑治疗失眠症的有效性和安全性。方法将38例患者随机分为马来酸咪哒唑仑组19例,佐匹克隆组19例,治疗2周,采用睡眠障碍量表(SDRS)评定疗效。结果马来酸咪哒唑仑组有效率为79.0%,佐匹克隆组有效率为73.7%,两者间差异无显著性。结论马来酸咪哒唑仑是一种有效、安全的治疗睡眠障碍的新药,值得临床推广应用。

Objective To explore the effectiveness and safety of midazolam maleate in treating patients with insomnia. Methods 38 cases were randomly divided into 2 groups： midazolam maleate group and zopiclone group, 19 cases in each; after 2 -week treatment, SDRS was adopted to evaluate the curative effect. Results The effective rate of midazolam maleate groups was 79.0% while that of zopiclone group was 73.7%, there existed no significant difference between the 2 groups. Conclusions Midazolam maleate is an effective, safe new drug for patients with sleeping disorder and worthy of being widely applied in clinic.