期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

同源相同性连锁不平衡作图构建高清晰度的QTL图谱

Construction of fine QTL mapping based on IBD-linkage desequilibrium analysis
下载PDF
导出
摘要 QTL(quantitative trait loci)定位是近年来遗传学研究的一个重要内容,基于不同的遗传标记、不同的研究群体和不同的试验设计,运用标记—连锁分析可以把QTL成功地定位在染色体的某一特定区域.该法的一个明显不足是QTL图谱的清晰度必须依赖样本的规模以及标记的密度.许多研究表明,连锁不平衡分析是实现QTL精细定位的行之有效的方法.现就基于同源相同性连锁不平衡作图构建高清晰度QTL图谱的研究方法进行了综述,并对其应用前景进行了展望. QTL（quantitative trait loci） loclization has become a focus in genetic studies in recent years. Based on different genetic markers, diffierent research groups and different expriment designs, QTL can be localized to a certain region of chromosomes by applying marker-linkage analysis. However, the resolution of the QTL mapping greatly depends upon the size of the sample and the density of the marker,which is the weakness of marklinkage analysis method. Many studies demonstrated that linkage disequilibrium analysis is an effective way to implement fine QTL location.
作者 饶友生 王樟凤
机构地区 江西教育学院生物技术研究所
出处 《南昌工程学院学报》 CAS 2009年第3期1-4,共4页 Journal of Nanchang Institute of Technology
基金 江西省教育厅科学技术研究项目(GJJ8469) 国家高技术研究发展计划(863计划)项目(2006AA10A120)
关键词 QTL 连锁不平衡 同源相同性 精细定位 quantitative trait loci linkage disequilibrium identical by descent fine mapping
分类号 Q348 [生物学—遗传学]
  • 相关文献

参考文献15

  • 1Hirschhorn J N,Lohmueller K,Byrne E,et al.A comprehensive review of genetic association studies[J].Genet Med,2002,(4):45-61.
  • 2Andrew G Clark.Finding genes underlying risk of complex disease by linkagedisequilibrium mapping[J].Current Opinion in Genetics & Development,2003,(13):296-302.
  • 3Meuwissen THE,Goddard ME.Prediction of identity by descent probabilities from marker-haplotypes[J].Genet Sel Evol,2001,33:605-634.
  • 4Meuwissen THE,Karlsen A,Lien S,et al.Fine mapping of a quantitative trait locus for twinning rate using combined linkage and linkage disequilibrium mapping[J].Genetics,2002,161:373-379.
  • 5McClurg P,Pletcher MT,Wiltshire T.Comparative analysis of haplotype association mapping algorithms[J].BMC Bioinformatics,2006,7(1):61-67.
  • 6饶友生,张细权.鸡单核苷酸多态性与高清晰度QTL图谱的构建[J].遗传,2007,29(4):393-398. 被引量：6
  • 7Georges M.Mapping,fine mapping,and molecular dissection of quantitative trait loci in domestic animals[J].Annu Rev Genomics Hum Genet.2007,8:131-162.
  • 8Hirano T,Watanabe T,Inoue K,et al.Fine-mapping of a marbling trait to a 2.9-cM region on bovine chromosome 7 in Japanese Black cattle[J].Animal Genetics,2007,39,79-83.
  • 9Grisart B,Coppieters W,Farnir F,et al.Positional candidate cloning of a QTL in dairy cattle:identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition[J].Genome Res,2002,12:222-231.
  • 10Kim ES,Shi Xianwei,Ozden Cobanoglu,et al.Refined mapping of twinning rate QTL on bovine chromosome 5 and analysis of IGF1 as a positional candidate gene[J].Journal of Animal Science,J Anim Sci,2008,1:1-39.

二级参考文献24

  • 1Johnson NJ.Searching for genetic determinants in new millennium.Nature,2000,405:847.
  • 2Lohmueller KE,Pearce CL,Pike M,Lander ES,Hirschhorn JN.Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to commondisease.Nat Genet,2003,33:177-182.
  • 3Peterson RJ,Goldman D,Long JC.Effects of world -wide population subdevision on ALDH2 linkage disequilivrium.Genome Res,1999,9:844-852.
  • 4Wong GK,Liu B,Wang J,Zhang Y,Yang X,Zhang Z,Meng Q,Zhou J,Li D.A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms.Nature,2004,432:717-725.
  • 5Sundstrom H,Webster MT,Ellegren H.Reduced variation on the chicken Z chromosome.Genetics,2004,167(1):377-385.
  • 6Berlin S,Ellegren H,Chicken WA.Genetically uniform chromosome in a highly variable genome.PNAS,2004,101:15967-15969.
  • 7Handley LJL,Ceplitis H,Ellegren H.Evolutionary strata on the chicken Z chromosome:Implications for sex chromosome.Evolution Genetics,2004,167:367-376.
  • 8Lahn BT,Page D.Four evolutionary strata on the human X chromosome.Science,1999,286:964-967
  • 9Axelsson E,Webster MT,Smith NGC,Burt DW,Ellegren H.Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomes.Genome Res,2005,15:120-125
  • 10Tatsuda K,Fujinaka K.Genetic mapping of the QTL affecting body weight in chickens using a F2 family.Br Poult Sci,2001,42(3):333-337.

共引文献5

南昌工程学院学报
2009年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部