铥激光膀胱病灶切除术加膀胱灌注吡柔比星预防腺性膀胱炎复发的初步研究

The effectiveness of intravesical instillation of pirarubicin after transurethral thulium laser resection of bladder lesions for preventing recurrence of cystitis glandularis

目的探讨腺性膀胱炎铥激光膀胱病灶切除术后应用吡柔比星膀胱内灌注化疗预防复发的疗效。方法81例病理证实的腺性膀胱炎患者，41例经尿道电切术后行吡柔比星膀胱内灌注（A组），40例铥激光膀胱病灶切除术治疗（B组），比较两组患者术后复发率及观察吡柔比星膀胱内灌注副反应。结果随访3～54个月，平均36个月，A组13例复发，B组11例复发，两组总复发率比较差异无统计学意义（P〉0．05）。结论腺性膀胱炎经尿道铥激光膀胱病灶切除术后应用吡柔比星膀胱内灌注能明显减少腺性膀胱炎复发，且副反应少，安全性较高，这一新技术操作安全，创伤小、并发症少，短期疗效显著。

Objectives To evaluate the therapeutic effect of intravesical instillation of pirarubicin （THP） in the cystitis glandularis after transurethral thulium laser resection of the bladder lesions. Methods of 81 cases of pathological proven cystitis glandularis ,41 cases were managed by intravesical instillation of pirarubicin after transurethral electroresection of bladder lesions （ group A） ,and the remaining 40 cases were managed by intravesical in- stillation of pirarubicin transurethral thulium laser resection of the bladder lesions （group B） . The recurrent rate and side effects between two groups were compared. Results After follow - up for 36 months （6 - 54 months） , there were 13 cases and ll cases of recurrence in group A and group B respectively. There was no significant difference in the recurrent rate between two groups （ p 〉 0. 05 ）. Conclusions Intravesicai instillation of pirarubicin after transurethral thulium laser resection of the bladder lesions can decrease the rerurrence of cystitis glandularis , and the incidence of side effects was lower. Management of transurethral thulium laser resection of the bladder lesions had good effect in short term ,with small trauma and complications.