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NKT细胞和HIV感染 被引量：1

NKT Cells and HIV Infection
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摘要 NKT细胞是一群表达半不变量T细胞受体(TCR)的淋巴细胞亚群,它识别由非多态性MHC-Ⅰ类分子CD1d呈递的糖脂。NKT细胞有免疫调节功能,抵抗自身抗原和病原体。最近研究发现,NKT细胞是HIV-1感染的靶细胞之一,且在HIV感染者体内选择性减少。本文着重讨论上述发现的机制、后果以及HIV-1感染治疗前景。 Natural killer T （NKT） cells are a subset of lymphocytes that express a semi-invariant T cell receptor （TCR） that recognizes glycolipids presented by the non-polymorphic MHC class I-like molecule CDld. NKT cells regulate a wide variety of immune functions against auto-antigens and pathogens. Recently, it was shown that NKT cells are targeted by HIV-1 and selectively lost in HIV-infected individuals. This review will focus on the mechanisms, consequences and therapeu tic implications of these findings
作者 黄孝军 侯炜
机构地区 武汉大学医学病毒学研究所/病毒学国家重点实验室 湖北民族学院
出处 《武汉大学学报（医学版）》 CAS 北大核心 2009年第4期556-560,共5页 Medical Journal of Wuhan University
关键词 NKT细胞 HIV-1感染 细胞因子 Natural Killer T Cell HIV Infection Cytokine
分类号 R392 [医药卫生—免疫学] R512.91 [医药卫生—内科学]
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参考文献10

  • 1Exley MA,He Q,Cheng O,et al.Cutting edge:com-partmentalization of Th1-like noninvariant CD1d-reac-tive T cells in hepatitis C virus-infected liver[].J Im-munol.2002
  • 2Vasan S,Poles MA,Horowitz A,et al.Function ofNKT cells,potential anti-HIV effector cells,are im-proved by beginning HAART during acute HIV-1 in-fection[].International Immunology.2007
  • 3Takahashi T,,Chiba S,Nieda M,et al.Cutting edge:analysis of human Vα24+CD8+NK T cells activatedby alpha-galactosylceramide-pulsed monocyte-deriveddendritic cells[].J Immunol.2002
  • 4Moll M,Snyder-Cappione J,Spotts G,et al.Expan-sion of CD1d-restricted NKT cells in patients with pri-mary HIV-1 infection treated with interleukin-2[].Blood.2006
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同被引文献23

  • 1张艳,魏海涛,陈元鼎.自然杀伤T细胞的研究进展[J].生物技术通报,2009,25(S1):10-14. 被引量：5
  • 2Yang JQ, Wen X, Liu H, Folayan G, Dong X, Zhou M, Van Kaer L, Singh RR. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model [J]. Arthritis Rheum, 2007, 56(4): 1219-1233.
  • 3Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies [J]. Immunol Today, 2000, 21(11): 573-583.
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  • 5Porcelli SA, Modlin RL. The CD1 system: antigenpresenting molecules for T cell recognition of lipids and glycolipids [J]. Annu Rev Immunol, 1999, 17: 297-329.
  • 6Brossay L, Jullien D, Cardell S, Sydora BC, Burdin N, Modlin RL, Kronenberg M. Mouse CD1 is mainly expressed on hemopoietic-derived cells [J]. J Imrnunol, 1997, 159 (3): 1216-1224.
  • 7Kawano T, Cui J, Koezuka v, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, Koseki H, Taniguchi M. CD1d-restricted and TCR-mediated activation of Va14 NKT cells by glycosylceramides [J]. Science, 1997, 278(5343): 1626-1629.
  • 8Juno lA, Keynan v; Fowke KR. Invariant NKT cells: regulation and function during viral infection [J]. PLoS Pathog, 2012, 8(8): e1002838.
  • 9Gumperz JE, Miyake S, Yamamura T, Brenner MB. Functionally distinct subsets of CDId-restricted natural killer T cells revealed by CD1d tetramer staining [J]. J Exp Med , 2002,195(5): 625-636.
  • 10HuaJ, Liang S, Ma X, Webb TJ, Potter JP, Li Z. The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity [J]. PLoS One, 2011, 6(11): e27038.

引证文献1

武汉大学学报（医学版）
2009年 第4期

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