盐酸氨溴索不同给药方式对预防新生儿早产肺透明膜病观察

The Preventive Effect of Different Delivery Ways of Ambroxol Hydrochloride on Hyaline Membrane Disease in Newborns

目的探讨盐酸氨溴索的不同用药方式预防新生早产儿肺透明膜病变(HMD)的疗效.方法将165例早产儿随机分为4组:静脉组、静脉雾化组、雾化组和对照组,监测经皮血氧饱和度和第3天的胸片,比较HMD的发病率、发病程度和经皮血氧饱和度开始下降的时间.结果静脉组和静脉雾化组HMD发病率,发病程度均低于对照组,发病时间延长,和对照组比较,有显著性差异(P<0.05).结论静脉和静脉联合雾化应用盐酸氨溴索能有效预防和减轻HMD的发生,疗效优于单纯雾化给药.

Objective To explore the preventive effect of ambroxol hydrochloride delivered by different ways on hyaline membrane disease in newborns. Methods 165 premature infants were divided randomly into 4 groups： intravenous injection group, intravenous injection plus atomizing inhalation group, atomizing inhalation group, and control group. We monitored the transcutaneous oxygen saturation and chest X-ray, compared the incidence and severity of HMD, and the time transcutaneous oxygen saturation began to decrease among the four groups. Results The incidence and severity of HMD were lower, and the onset time was longer in intravenous injection group and intravenous injection plus atomizing inhalation group than those in control group （P 〈 0.05） Gonelusion Intravenous injection and intravenous injection plus atomizing inhalation of ambroxol hydrochloride can prevent the incidence of HMD, and their effects are better than atomizing inhalation only.