深圳市福田区2000年至2008年麻疹发病率及人群抗体水平分析

Incidence and Antibody Concentrations in Patients with Measles in Futian District of Shenzhen from 2000 to 2008

目的通过调查深圳市福田区近8a来麻疹病人发病率及人群抗体水平,探讨我区麻疹控制策略,以最终实现2012年消除麻疹的工作目标.方法收集2000年至2008年深圳市福田区麻疹发病数据进行流行病学分析,采集血清标本进行麻疹IgG抗体水平检测.结果2000年至2008年,福田区麻疹发病有明显的季节性,且发病高峰后移.发病呈低年龄和大年龄两个高峰,0～1岁和20～35岁组发病数最高,50岁以上组无发病.不同年龄组麻疹抗体水平0～1岁组阳性率最低,20岁～组抗体平均滴度最低.外来务工人员麻疹抗体水平较低.结论保持常规免疫高接种率,加大查漏补种工作力度,适时开展强化免疫和强化疫点处理,及时做好重点人群的麻疹疫苗接种工作,降低成人麻疹的发病率,提高全人群免疫水平是我区控制麻疹的主要策略.

Objective To investigate the strategies for measles control in Futian district of Shenzhen from 2000 to 2008, so as to finally achieve the working goals of measles control and regional measles elimination in 2012. Methods Information on incidence of measles from 2000 to 2008 was collected for epidemiological analysis, and serum samples were carried out to detect the level of measles IgG antibody concentration. Results A clear seasonality was observed in measles dynamics from 2000 to 2008, and the incidence peak tended to be delay. The incidence had a characteristic of bimodal appearance, with one peak in young people and another in older people; the incidence in people less than 1 year old and between 20 and 35 years old was the highest, while no incidence cases were identified in people over 50 years. Among people with different age, the people less than 1 year old had the lowest antibody positive rate for measles, and people over 20 years old had the lowest mean antibody concentrations. Migrant workers had relatively lower measles antibody concentrations, becoming the focus population of measles prevention and control in our district. Conclusions The key strategies for measles control in our district should be considered. These strategies includ keeping the routine high vaccination rate, improving the vaccine surveillance activities, conducting timely enhancing vaccination programs, enhancinghandling strategy for epidemic area, focusing on measles vaccine inoculation work on the high risk population, reducing the incidence of human measles and improving the population immunity.