内皮素对肝血流量影响的实验研究

EFFECT OF ENDOTHELIN 1 ON HEPATIC BLOOD FLOW IN RATS

选用Ｗｉｓｔａｒ大鼠２０只，随机分为对照组、内皮素１（ＥＴ１）组、ＥＴ１＋硝基左旋精氨酸组和ＥＴ１＋前列环素＋消炎痛组，每组５只。采用氢气清除法观察ＥＴ１对肝血流量的影响以及一氧化氮（ＮＯ）和前列环素（ＰＧＩ２）对ＥＴ１生物学效应的调节作用。结果显示：ＥＴ１能使肝血流量迅速降低，并且持续时间较长；ＮＯ及ＰＧＩ２可部分拮抗ＥＴ１的生物学效应。

In order to study effect of endothelin (ET 1) on hepatic blood flow in rats and effect of nitric oxide (NO) and prostacyclin (PGI 2) on ET 1 biological function, 20 rats were randomized into control, ET 1, ET 1 plus nitric L arginine, ET 1 plus prostacyclin and indomethen groups. The result showed that ET 1 decreased hepatic blood flow and lasted for longer time. NO and PGI 2 may antagonize the biological action of ET 1 during endotoxemia. Therefore, the endothelium derived vascular factors may regulate hepatic blood flow.