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氧化应激与白癜风 被引量：7

The role oxidative stress plays in the pathogenesis of vitiligo
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摘要 白癜风病因复杂，尚未明确。目前学术界关于其发病机制的讨论大致有两派观点：一方认为白癜风是一种原发性的自身免疫性疾病，另一方认为它本质上是一个氧化应激相关的皮肤病。本综述旨在从氧化应激这一方面回顾、总结白癜风发病机制的最新研究及相关的治疗进展。
作者 周舟 高天文
机构地区 第四军医大学西京医院全军皮肤病研究所
出处 《中国美容医学》 CAS 2009年第7期1037-1039,共3页 Chinese Journal of Aesthetic Medicine
关键词 氧化应激 白癜风 自身免疫性疾病 发病机制 原发性 学术界 皮肤病
分类号 R742.5 [医药卫生—神经病学与精神病学] R758.41 [医药卫生—皮肤病学与性病学]
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参考文献33

  • 1Schallrenter KU,Bahadoran P,Picardo M,et al.Vitiligo pathogenesis:autoimmune disease,genetic defect,excessive reactive oxygen species,calcium imbalance,or what else [J].Exp Dermatol,2008,17:139-140.
  • 2Schailrenter KU,Moore J,Wood JM,et al.In vivo and in vitro evidence for hydrogen peroxide H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase[J].J lnvestig Dermatol Symp Proc,1999,4:91-96.
  • 3Casp CB,She JX,McCormack WT.Genetic association of the catalase gene (CAT) with vitiligo susceptibility[J].Pigment Cell Res,2002,15:62-66.
  • 4Gavalas NG,Akhtar S,Gawkrodger DJ,et al.Analysis of allelic variants in the catalase gene in patients with the skin depigmenting disorder vitiligo [J].Biochem Biophys Res Commun,2006,345:1586-1591.
  • 5Park HH,Ma E,Uhm YK,et al.Association study between catalase gene polymorphisms and the susceptibility to vitiligu in Korean population[J].Exp Dermatoi,2006,15:377-380.
  • 6Em S,Laddha NC,Chatterjee S,et al.Association of eatalase T/C exon 9 and glutathione peroxidase eodon 200 polymorphisms in relation to their activities and oxidative stress with vitiligo susceptibility in Gujarat populafion[J].Pigment Cell Res,2007,20:405-407.
  • 7Wood JM,Gibbons NC,Chavan B,et al.Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indieates structural changes in the enzyme active site,NADPH-binding and tetramerization domains:a genetic predisposition for an altered catalase in patients with vitiligo[J]? Exp Dermatol,2008,17:366-371.
  • 8Uhm YK,Yoon SH,Kang IJ,et al.Association of glutathione S-transferase gene polymorphisms(OSTM 1 and GSTT1) of vitiligu in Korean population[J].Life Sci,2007,81:223-227.
  • 9Agrawal D,Shajil EM,Marfatia YS,et al.Study on the antioxidant status of vitiligo patients of different age groups in Baroda[J].Pigment Cell Res,2004,17:289-294.
  • 10Koca R,Annutcu F,Altinyazar HC,et al.Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligu [J].Clin Exp Dermatol,2004,29:406-409.

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中国美容医学
2009年 第7期

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