缓解柳氮磺吡啶治疗溃疡性结肠炎引起胃肠道反应15例分析

Analysis on alleviating adverse gastrointestinal events in patients with ulcerative colitis received SASP

回顾分析SASP治疗溃疡性结肠炎引起胃肠道不良反应15例患者的临床表现。给予降低SASP剂量;恶心、食欲不振或上腹胀者用多潘立酮;上腹不适或烧灼感者用PPI;二者皆有给予多潘立酮及PPI两种药物治疗等。15例患者中发生恶心、食欲不振11例,上腹不适7例,上腹烧灼感2例,上腹胀1例。降低SASP剂量5例,给予多潘立酮3例,雷贝拉唑等PPI2例,多潘立酮及PPI治疗5例,15例患者皆症状减轻更好耐受治疗。降低剂量、用多潘立酮或/及质子泵抑制,可能缓解SASP引起的胃肠道不良反应,溃疡性结肠炎患者更易耐受治疗。

Clinical manifestations of gastrointestinal side-effects induced by SASP of 15 patients were analyzed. Patients with nausea, anorexia or bloating received domperidone, patients with upper abdominal discomfort or burn received PPI, and cases with both features received domperidone and PPI. Nausea and anorexia （ 11 ） , upper abdominal discomfort （7） , epigastrie burn （2） , upper abdominal bloating （1） occurred in 15 patients. Five patients received a lower dose SASP, 3 patients received domperidone, 2 patients received PPI such as rabeprazole and 5 patients received domperidone and PPI. Fifteen patients all bad better relief of adverse gastrointestinal symptoms. SASP may be better tolerated by receiving a lower dose, or domperidone or/and PPI in UC patients with gastrointestinal side-effects induced by SASP.