胰腺癌患者抑郁症状与生存质量的关系

Relationship between symptoms of pancreatic cancer-related depression and quality of life of patients

目的探讨胰腺癌相关抑郁与生存质量的关系。方法纳入2007年6月至2008年10月广州地区3家医院收治的50例胰腺癌住院患者，分别采用汉密顿抑郁量表24（HAMD-24）测量胰腺癌患者的抑郁情况，欧洲癌症研究与治疗组织（EORTC）癌症患者生存质量核心量表（QLQ—C30）与胰腺癌患者生存质量特异量表（QLQ—PAN-26）量表评价患者生存质量。结果50例胰腺癌患者中，39例发生抑郁（78．0％），其中12例（30．8％）属于严重抑郁症；化疗患者的抑郁发生率显著高于手术治疗[92．3％（24／26）比62．5％（15／24），P=0．011]。伴发抑郁的胰腺癌患者在角色功能、情绪功能、社会功能方面的生存质量得分均显著低于无抑郁的患者，在疲倦、疼痛、食欲丧失症状方面则均明显高于无抑郁胰腺癌患者（均P〈0．05）。结论胰腺癌患者多存在抑郁情感障碍，且抑郁能显著降低患者生存质量。

Objective To investigate the relationship between symptoms of pancreatic cancerrelated depression and quality of life of patients. Methods Fifty inpatients with pancreatic cancer from 3 Guangzhou hospitals between June 2007 and October 2008 were enrolled. Hamilton rating scale for depression-24 （HAMD-24） questionnaire was used to assess the degree of depression. Quality of Life （QoL） was evaluated by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-30 （EORTC QLQ-C30） and QLQ-PAN-26 respectively. Results Thirty-nine （78.0%） of these patients reported depression and 12 patients （30. 8% ） had severe depression. The incidence of depression in pancreatic cancer patients with chemotherapy was 92.3% （24/26） , which was significantly higher than that of patients with surgical therapy （62.5% , 15/24） （ P = 0.011 ）. The QoL of pancreatic cancer patients with depression in role functioning, emotional functioning and social functioning was significantly worse than that of patients without depression. The symptoms of fatigue, pain and appetite loss in pancreatic cancer patients with depression were significantly more than those without depression （ P 〈 0.05 ）. Conclusions Depressive symptoms are common psychological disturbance in pancreatic cancer patients. Moreover, depression significantly lowers quality of life for pancreatic cancer patients.