糖尿病合并颈动脉硬化患者认知功能的研究

The research of diabetes mellitus and carotid artery atherosclerosis patients' cognitive function

目的探讨糖尿病合并颈动脉硬化患者认知功能的改变情况。方法收集86例糖尿病颈动脉硬化患者,使用简易智能状态检查表(MMSE)对患者认知功能进行检查;对患者作颈动脉超声检查并按动脉硬化的程度分组,比较糖尿病患者颈动脉硬化程度血清与认知功能的关系,并与40例健康人进行比较。结果糖尿病颈动脉增厚患者在注意力和计算力及总分方面显著低于对照组(P<0.05);糖尿病颈动脉斑块患者在定向力、注意力和计算力、记忆力、语言和总分方面显著低于对照组(P<0.05,P<0.01)。血糖与颈动脉硬化程度呈显著正相关(P<0.05);血糖与记忆力和总分呈显著负相关(P<0.05);颈动脉硬化程度与注意力和计算力、记忆力、语言和总分呈显著负相关(P<0.05)。结论糖尿病患者也存在一定程度的认知功能下降,认知障碍表现为语言、记忆和计算能力下降等。

Objective To study the cognitive function of diabetes mellitus （DM） combined with carotid atherosclerosis patients. Methods 86 DM with carotid artery atherosclerosis patients＇ cognitive function were examined by Mini-Mental State Examination （MMSE）. In the meantime, all carotid arteries of 86 cases were examined with color Doppler ultrasound. The subjects were divided into 2 groups according to the severity of lesion of carotid artery. The cognitive function was compared among different groups. Results Compared with control group, the levels of attention, calculation and total scales in the DM patients with carotid atherosclerosis were lower, and the levels of orientation, attention and calculation, recall, language and total scales in the DM patients with carotid plaques were lower （ P 〈 0. 05 ）. And there was a positive relationship between the degree of carotid atherosclerosis and the level of serum glucose. There was negative relationship between patients＇ glucose and recall and total scales; and there was negative relationship between patients＇ carotid atherosclerosis and attention and calculation, recall, language and total scales （ P 〈 0. 05 ）. Conclusions There are cognitive dysfunctions, such as attention, calculation and language, in DM with carotid atherosclerosis patients.