扩散加权成像鉴别兔炎性及转移性淋巴结肿大的实验研究

Experiment study on MR diffusion weighted imaging in rabbit models of lymphadenopathy： comparison between inflammatory and metastatic lymph node

目的探讨DWI鉴别兔良、恶性淋巴结肿大的价值。方法对18只炎性增生性兔淋巴结（34个）肿大模型和9只肿瘤转移性兔淋巴结（18个）肿大模型进行常规MR和DWI检查，并采用独立样本t检验比较2组淋巴结短径和ADC值的差异。结果对34个炎性增生型淋巴结和18个肿瘤转移性淋巴结进行了观察，炎性组和转移组淋巴结的短径分别为（8．14±2．79）和（6．29±1．48）mm，差异无统计学意义（t=2．624，P〉0．05）。炎症组和转移组淋巴结的ADC值分别为（1．19±0．31）×10。和（1．31±0．27）×10^-3 mm^2／s，差异无统计学意义（t=1．449，P〉0．05）。结论DWI可显示肿大的淋巴结，但其ADC值差异不大，不足以作为比较并鉴别淋巴结良恶性的手段。

Objective To investigate the value of MR DWI in comparing inflammatory with metastastic lymph node in animal models of lymph disease. Methods Eighteen rabbits with benign lymphadenopathy and 9 rabbits with malignant lymphadenopathy underwent routine MRI and DWI examination. Independent-samples t test was used to compare the sizes and apparent diffusion coefficient （ADC） values between the two groups. Results Thirty-four inflammatory lymph nodes and 18 metastastic lymph nodes were observed . The size of lymph nodes was （8.14 ±2.79） and （6. 29 ±1.48） mm in the benign and malignant groups, respectively . There was no significant statistical difference between the sizes of the two groups （t =2.624,P 〉0.05）. Mean ADC value of lymph nodes was （1.19 ±0.31）× 10 ^-3 mm^2/s and （ 1.31 ±0. 27） × 10^-3 mm^2/s in the benign and malignant groups, respectively. There was no significant statistical difference between the ADC values of benign and malignant lymph nodes （t = 1. 449,P 〉0. 05）. Conclusion DWI sequence can be used to show lymphadenopathy, but the ADC value is insufficient to differentiate benign lymph nodes from malignant lymphadenopathy.