摘要
目的探讨肿瘤转移抑制因子nm23-H1基因在肝癌组织中的表达以及与转移、复发、预后的关系。方法应用免疫组织化学SP法对36例肝癌组织、30例正常组织进行nm23-H1基因蛋白检测,并追踪随访1年。结果肝癌低分化组中nm23-H1基因蛋白表达阳性率为26%,明显低于高、中分化组及正常组织(P<0.05),nm23-H1基因蛋白表达在肝内转移组明显低于无肝内转移组,两组间差异有统计学意义(P<0.01);nm23-H1基因蛋白表达在术后复发组明显低于术后无复发组。结论nm23-H1基因蛋白与肝癌的转移、复发及预后密切相关。
Objective The purpose of this study was to investigate the association between the expression of genic protein nm23-H1 and clinical metastasis and relapse in patients with primary liver cancer. Methods nm23- H1 genic protein was detected by immunohistochemical method of strept-avidin-peroxidase （SP） in 36 primary liver cancer, and tracing for 1 year. Results The positive rate of nm23 H1 cxpresion in the low differentiated primary liver cancer tissues（26 % ）was significantly lower than that in the high and middle differentiated cancer tissues, and the normal tissues（P〈0.05）, the positive rate of nm23-H1 expression in liver cancer without lymph node metastasis was significantly lower than that in liver cancer with lymph node metastasis （P〈0.01）. Conclusion nm23-H1 expression is closely related to the metastasis and relapse of liver cancer.
基金
山西省教委科技项目(20051024)
关键词
肝肿瘤
基因
肿瘤抑制
肿瘤转移
复发
Liver neoplasms
Genes, tumor suppressor： Neoplasm metastasis
Recurrence
