溴甲烷中毒家兔脑电地形图的变化

THE STUDY OF ELECTRICAL ACTIVITY MAPPING IN METHYL BROMIDE POISIOND RABBITS

目的探讨溴甲烷对高级中枢神经系统电生理学的影响。方法采用呼吸道吸入法制成家兔急性溴甲烷中毒模型，观察中毒后家兔脑电地形图各频段功率值的变化。结果与正常对照组比较，染毒兔的脑电活动明显抑制，脑波慢化且呈弥漫性。地形图表现为δ，θ频段功率值明显升高（Ｐ＜０．０１），而反映大脑皮层兴奋过程的β频段功率则明显降低（Ｐ＜０．０５），α频段染毒后功率无明显变化（Ｐ＞０．０５）。结论溴甲烷对中枢神经系统具有一定的毒性作用，可明显抑制大脑的生物电活动，从而影响脑的高级功能。

Objective To observe the effect of methyl bromid(CH3Br) on biologicelectricity of cerebral cortex in rabbit.Method The model of CH3Br poisoned rabbits were made by inhaling the air mixed with CH3Br.The changes of brain electricity activity mapping(BEAM) were observed andrecorded.Result The brain electrical activity was depressed inpoisoned rabbits.There was an inseased voltage in δ and θ frequency and a decreased voltage in BEAM of poisoned rabbits.There was a sigenificant difference between experimental and control groups(P<[WT5”BZ]0.01,P<0.05). But there was no sigificant change in (P>0.05).Conclusion CH3Br has a poisonous effect on central nervous system.It influences the superior function of brain by inhibiting the biologic electrical activity of cerebral cortex.