纳络酮治疗新生儿缺氧缺血性脑病临床分析

Naloxone treatment of neonatal hypoxic-ischemic encephalopathy Analysis

目的：探讨纳络酮治疗新生儿缺氧缺血性脑病（HIE）的效果。方法：收集80例中重度HIE，治疗组40例，对照组40例，两组均采用同样严格的支持疗法和对症处理，在此基础上治疗组给予纳络酮，第1天给予0.1mg／kg静注，继之以（0.03-0.05）mg／（kg·h）速度静脉滴注，连用3d，对重度HIE伴有呼吸衰竭和昏迷的患儿，疗程延长至5d。结果：治疗组用药3d后，总有效率为95％；对照组用药3d后，总有效率72.5％。治疗组预后优于对照组。结论：纳络酮治疗HIE可使症状消失时间缩短，减轻中重度HIE的并发症，使死亡率明显降低，减少后遗症，改善预后方面取得了满意的效果。

objectives ：To investigate the therapeutic effect of Naloxone on HIE. Methods 80 newborns with mild and severe HIE were randomly divided into two groups. 40 cases in one group were treated with general ways patients in therapy group received Naloxone at first ay 0.1mg/kg inject next 0.03-0.05mg/kg ingtt 3days to severe HIE. Results ：The therapy group＇s totle effective rate is 95% , The control group＇s totle effective rate is 72.5% after treating 3 days . Conclusions ：Naloxone HIE may shorten the period of treatment, reduce HIE Incidence, decrease death rate.